The etiology and pathogenesis of fatigue are largely unknown. Sub-health state of fatigue is one of the most common sub-health types with that fatigue as the chief complaint. It has attracted extensive attention with the increasing incidence of sub-health in recent years. Sub-health status is defined as the decline in vitality, physiological function, and adaptation capacity, but in general not meeting the diagnostic criteria for clinical or sub-clinical diseases. It has become one of the main factors harmful to human's physical and mental health with a serious decline in work efficiency and life quality. It is ubiquitous in sub-health and various diseases, such as Parkinson’s, major depressive disorder, schizophrenia, and cancer. Fatigue is a non-specific symptom with certain heritability. It is a physiological manifestation of body's self-regulation, and a pathological result of certain diseases. The complex network technology was suitable for correlation analysis of symptoms and indexes in fatigue population, and tongue and pulse data had a certain diagnostic contribution to the classification of fatigue population.įatigue is a state in which the body cannot initiate or maintain a certain intensity of activity, or manifest a pathological dysfunction during the initiation or maintenance of voluntary activity.
The canonical correlation coefficient of tongue and pulse data in the disease fatigue group was 0.42 ( P < 0.05), on the contrast, correlation analysis of tongue and pulse in the sub-health fatigue group showed no statistical significance. The node-importance difference indicated that the diagnostic contribution rate of the same symptom to the two groups was different. Some similarities were found in the core symptoms of sub-health fatigue and disease fatigue population, but with different node importance. Simultaneously, canonical correlation analysis was used to analyze the objective tongue and pulse data between the two groups of fatigue population and analyze the distribution of tongue and pulse data.
#Canonical correlatio spss version 25 software
Pajek software was used to construct core symptom/index network and core symptom-index combined network. Complex network technology was used to screen out core symptoms and Western medicine indexes of sub-health fatigue and disease fatigue population. In this study, 2632 physical examination population were divided into healthy controls, sub-health fatigue group, and disease fatigue group. Establishing an objective evaluation method for diagnosing disease fatigue and non-disease fatigue by combining clinical symptom, index, and tongue and pulse data is of great significance for clinical treatment timely and effectively. Many clinical practices and researches have shown that tongue and pulse conditions reflect the body's overall state. Due to the lack of objective diagnostic criteria, it is often neglected in clinical diagnosis, especially in the early stage of disease. It is closely related to people's physical and mental health. Fatigue is a kind of non-specific symptom, which occurs widely in sub-health and various diseases.